HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels
نویسندگان
چکیده
1Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands; 2Institut National de la Santé et de la Recherche Médicale U770, Le Kremlin-Bicêtre, France; Univ Paris-Sud, Université Paris-Sud 11, Le Kremlin-Bicêtre, France; 3Department of Haematology, Haemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, the Netherlands; 4Department of Haematology, Erasmus University Medical Center, Rotterdam, the Netherlands; 5Department of Haematology, Medical University of Lille, Hôpital Cardiologique, Lille, France; 6Centre d’Exploration Biologique des Maladies Hémorragiques et Thrombotiques, Centre Hospitalier Universitaire, Nantes, France; 7Van Creveldkliniek, University Medical Center Utrecht, Utrecht, the Netherlands
منابع مشابه
Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels.
To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in A(1)A(1) individuals and higher in A(1)O(1) than in A(2)O(1) or O(1)O(1) individual...
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Type Vicenza variant of von Willebrand disease (VWD) is characterized by a low plasma von Willebrand factor (VWF) level and supranormal VWF multimers. Two candidate mutations, G2470A and G3864A at exons 17 and 27, respectively, of the VWF gene were recently reported to be present in this disorder. Four additional families, originating from northeast Italy, with both mutations of type Vicenza VW...
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